an approach to the design of a particulate system for oral protein delivery .ii. preparation and stability study of rhgh-loaded microspheres in simulated gastrointestinal fluids

the delivery of therapeutic proteins has gained momentum with development of biotechnology. however, large molecular weight, hydrophilic nature and susceptibility to harsh environment of gastrointestinal tract (git) resulted in low absorption. the main objective of this work was the design of a particulate system for oral delivery of recombinant human growth hormone (rhgh) on the basis of particle uptake mechanism in git. biodegradable protein-loaded microspheres were prepared using resomers (rg207, rg756 and rg505) by double emulsion methods.